Neurobiology of Disease Induction of the Phase II Detoxification Pathway Suppresses Neuron Loss in Drosophila Models of Parkinson’s Disease
نویسندگان
چکیده
Kien Trinh,1 Katherine Moore,1 Paul D. Wes,4 Paul J. Muchowski,3 Joyoti Dey,2 Laurie Andrews,1 and Leo J. Pallanck1 1Department of Genome Sciences and 2Molecular and Cellular Biology Program, University of Washington, Seattle, Washington 98195, 3Gladstone Institute of Neurological Disease and Departments of Biochemistry and Biophysics, and Neurology, University of California, San Francisco, San Francisco, California 94158, 4Elan Pharmaceuticals, South San Francisco, California 94080
منابع مشابه
Dopamine-Synthesizing Neurons: An Overview of Their Development and Application for Cell Therapy
Cell-gene therapy is a dynamic constituent of novel medical biotechnology. Neurodegenerative disordersin which damage to or demise of specific brain cell types plays central role, are clear examples of diseasecandidate for cell replacement therapy. Dopaminergic (DAergic) neurons biosynthesize dopamine, a vitalneurotransmitter in the central nervous system. Due to the involveme...
متن کاملGlobal gene expression analysis using microarray to study differential vulnerability to neurodegeneration
Neurodegenerative disorders such as Parkinson’s disease, motor neuron disease and Alzheimer’s disease is characterized by loss of specific cells within certain regions of the brain. One of the most compelling questions is to determine why specific cell populations are vulnerable to neurodegeneration. We addressed this question by studying global gene expression changes using an animal model of ...
متن کاملGlobal gene expression analysis using microarray to study differential vulnerability to neurodegeneration
Neurodegenerative disorders such as Parkinson’s disease, motor neuron disease and Alzheimer’s disease is characterized by loss of specific cells within certain regions of the brain. One of the most compelling questions is to determine why specific cell populations are vulnerable to neurodegeneration. We addressed this question by studying global gene expression changes using an animal model of ...
متن کاملCinnamaldehyde attenuates dopaminergic neuronal loss in substantia nigra and induces midbrain catalase activity in a mouse model of Parkinson’s disease
Background and Objective: Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease that affects 3% of the population. PD involves a progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNc) and subsequent loss of dopamine. Dopamine depletion leads to movement dysfunction and is accompanied with tremor, rigid muscle...
متن کاملThe effects of aqueous cinnamon bark extract and cinnamaldehyde on neurons of substantia nigra and behavioral impairment in a mouse model of Parkinson’s disease
Background and Objective: Parkinson's disease (PD) is characterized by a progressive loss of dopaminergic neurons in substantia nigra. In recent years, there have been interests in the role of the free radical damage in PD. Cinnamon and its derivative, cinnamaldehyde acts as powerful antioxidant and anti-inflammatory agents. This research focused on the effects of cinnamon extract and cinnamald...
متن کامل